Palmitoylethanolamide (P.E.A.) for Chronic Pain and Inflammation.
PEA, is a naturally occurring fatty acid amide produced within our cells. Since the initial discovery of P.E.A there have been around 500 separate studies on the properties of PEA for human health. It has been shown to help relieve pain, inflammation, fever, boosts the immune system and helps with allergies. It has been shown to be very safe and virtually side effect free. It is non addictive and is NOT psychoactive. It can be safely combined with most pharmaceutical drugs as no dangerous interactions have been found.
Due to being so effective and well tolerated many pain specialists are now recommending it. PEA is available over the counter without a prescription.
PEA has been found to be effective with the following pain conditions:
- Neck Pain and Whiplash Injury
- Tooth/dental (molar) surgery pain
- Chronic Low Back Pain
- Pelvic pain/disorders
- Prostate disease
- Chronic (Unexplained) Pain
- Visceral pain
- Carpal Tunnel
- Neural/Neuropathic pain- cancer chemotherapy
- Sciatic pain
- Multiple Schlerosis
- Neuralgia, neuralgic pain
- Pains/spasms after a stroke
- May help in Inflammatory Bowel Disease
- Diabetic Neuropathic pain
- Many others…
The usual dose is 600mg twice a day with food giving a total of 1200mg a day. Relief of symptoms usually occur within 1 to 3 weeks. The dose can be doubled after 4 weeks if the initial dose was ineffective. If there is no improvement after 3 months then there is no need to continue as it may take this long before any relief is achieved.
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2.Keppel Hesselink, J.M., Hekker, T.A. 2012. Therapeutic utility of palmitoylethanolamide in the treatment of neuropathic pain associated with various pathological conditions: a case series Journal of Pain Research 5:437 – 442
3.Keppel Hesselink JM, Kopsky DJ, Treatment of chronic regional pain syndrome type 1 with palmitoylethanolamide and topical ketamine cream: modulation of nonneuronal cells. Journal of Pain Research 2013
4.Keppel Hesselink, J M, Tineke de Boer, and Renger F. Witkamp. Review Article. Palmitoylethanolamide: A Natural Body-Own Anti-Inflammatory Agent, Effective and Safe against Influenza and Common ColdInternational Journal of Inflammation Volume 2013 (2013), Article ID 151028, 8 pages http://dx.doi.org/10.1155/2013/151028
5.Keppel Hesselink JM. Chronic idiopathic axonal neuropathy and pain, treated with the endogenous lipid mediator palmitoylethanolamide: a case collection. International Medical Case Reports Journal Published Date September 2013 Volume 2013:6 Pages 49 – 53