Palmitoylethanolamide (P.E.A.), is a naturally occurring fatty acid amide produced within our cells. Since the initial discovery of P.E.A there have been around 500 separate studies on the properties of P.E.A. for human health. It has been shown to help relieve pain, inflammation, fever, boosts the immune system and helps with allergies.
It’s use has been most popular with pain sufferers as it can be used as a natural pain remedy for chronic pain, acute pain, inflammation and neuropathic pain such as diabetic neuropathic pain, sciatic pain, CRPS, pelvic pain and entrapment neuropathic painstates. It has been shown to be very safe and virtually side effect free.
The usual dose is 400mg taken three times a day with food giving a total of 1200mg a day. The dose can be increased up to 2400 mg daily after 4 weeks if the initial dose was ineffective. If there is no improvement after 3 months then there is no need to continue. Like many pain killers it may take this long before any relief is achieved.
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2.Keppel Hesselink, J.M., Hekker, T.A. 2012. Therapeutic utility of palmitoylethanolamide in the treatment of neuropathic pain associated with various pathological conditions: a case series Journal of Pain Research 5:437 – 442
3.Keppel Hesselink JM, Kopsky DJ, Treatment of chronic regional pain syndrome type 1 with palmitoylethanolamide and topical ketamine cream: modulation of nonneuronal cells. Journal of Pain Research 2013
4.Keppel Hesselink, J M, Tineke de Boer, and Renger F. Witkamp. Review Article. Palmitoylethanolamide: A Natural Body-Own Anti-Inflammatory Agent, Effective and Safe against Influenza and Common ColdInternational Journal of Inflammation Volume 2013 (2013), Article ID 151028, 8 pages http://dx.doi.org/10.1155/2013/151028
5.Keppel Hesselink JM. Chronic idiopathic axonal neuropathy and pain, treated with the endogenous lipid mediator palmitoylethanolamide: a case collection. International Medical Case Reports Journal Published Date September 2013 Volume 2013:6 Pages 49 – 53