Natural Hair Loss Treatment
Potassium ion channels exist within the dermal papilla cells of human hair follicles and have been the target for hair loss treatments with such medications such as Minoxidil, a potassium channel agonist. Potassium ion channels have been implicated in a vast array of diseases ranging from Androgenetic Alopecia to Diabetes. These small pore-forming protein structures control the transport of potassium ions across the hair follicle’s cell membranes and are essential for maintaining the follicle’s full biological activity and function.
It has been conclusively shown that in Androgenetic Alopecia the function of potassium channels within hair follicles progressively degrade. The result is reduced membrane potential and impaired ion transfer across the follicle’s cellular membranes –culminating over time in atrophying follicles and loss of hair.
A research team led by Dr Thomas Whitfield PhD, formulated, tested and patented an oral complex of nutrients that essentially have the same effect on potassium channels and hair growth as oral minoxidil without side effects, and significant cross over anti-aging health benefits.
This complex of nutrients simply consist of a combination of Potassium chloride, Carnitine tartrate, Branched Chain Amino Acids, Niacin, and Biotin.
According to the research, this particular combination of nutrients has the effect of:
• Boosting energy levels in the hair follicles
• Maintaining The Cell Membrane Potential of Hair Follicles*
• Stimulating de novo Synthesis of Potassium Channels in Hair Follicles
• Stimulating Potassium Channel Activity & Functionality
• Promotion of Hair Growth by Hyperpolarizing Hair Follicles
Studies have shown that L-carnitine stimulates human hair growth; via its ability to increase proliferation and decrease apoptosis in follicular cells. Carnitine literally increases the energy supply to the hair follicle matrix, which is necessary for the full functioning of potassium channels in hair follicles.
According to the research this combination stimulates the synthesis of cardiolipin, a key component of the plasma membrane of dermal papilla cells in hair follicles. Cardiolipin plays a crucial role in maintaining the potential and integrity of hair follicle cell membranes. In short it provides the ideal lipid environment for potassium channels to flourish and function at peak efficiency.”
The specific potassium channel found in human hair follicles is comprised of the Branched Chain Amino Acids, L-Leucine, Isoleucine and Valine.
L-carnitine helps maintain cellular energy metabolism by assisting in the transport of fat through the cell membrane and into the mitochondria within the cell, where fats are oxidized to produce the cellular energy ATP. This enhances potassium channel function and facilitates ion transport across the cellular membranes.
Niacin is structurally related to minoxidil and both maintains potassium channel function, which like oral minoxidil, stimulates hair growth.
Like oral minoxidil, this specific combination of compounds results in the hyper-polarization of the follicles membranes, which increase the size of miniaturized follicles, resulting in the gradual re-densification of hair over time with continued usage.
In addition we also incorporate Vitamin D and Zinc which are also essential for hair growth.
Our lab produces a combination which contains the following as a daily dose:
Potassium Chloride 191 mg.
L-Carnitine-L-Tartrate 800 mg.
Isoleucine 75 mg.
Valine 75 mg.
Zinc 20mg (as picolinate).
Vitamin D 1000iu
L-Carnitine–L-tartrate promotes human hair growth in vitro
Volume 16, Issue 11, pages 936–945, November 2007
Kerstin Foitzik1,2, Edo Hoting3, Thomas Förster4, Paolo Pertile5, Ralf Paus2