Osteoarthritis treatment with Pentosan
Pentosan sulfate is derived from beech wood trees and has been approved in Australia for human use as tablets for the treatment of Interstitial cystitis. It is also approved in veterinary use as an injection for the treatment of arthritis. It stimulates re-growth of new cartilage in the joint which can treat osteoarthritis. It does this by promoting cartilage synthesis and inhibits its breakdown. It also improves the bio-synthesis of high molecular weight hyaluronan, a key component of joint fluid. And finally, it increases blood flow through the capillaries that serve the cartilage cells themselves. If you increase blood flow to these cells, they’re more likely to stay healthy and arthritis-free; there’s increasing suspicion that poor blood flow itself may be a major contributor to osteoarthritis.
Pentosan is not a new medication, having been discovered in 1947 and used in Europe for more than 50 years in various forms, most notably for treating bladder inflammation and for veterinary use on animals with arthritis. Despite this long history of use, no extensive human clinical trials have been conducted for its use in osteoporosis, until recently.
For anyone, patient or physician, familiar with the suffering from arthritis, this is an extraordinary discovery. The amount of time it takes to regenerate enough cartilage to be pain free depends upon where in the body the arthritis is located. Since the hip joint is the largest joint, it takes the longest to repair. The knee joint will take less time, and the hands and spine will respond the quickest. Essentially, you use the product until you are out of pain.
Pentosan taken orally as tablets exhibits poor absorption so Dr. Roby Mitchell (Dr Fitt), a US doctor, developed Pentosan Nasal Spray. He has had a great deal of success treating patients – even those well into their 80′s!
Pentosan Sterile Nebules are also available with the use of a nebulizer helps administer it deep into the lung for maximum benefits.
Pentosan SQ injections are also available.
Pentosan is safe and carries no toxicity. It will create a mild blood thinning effect, so patients taking any blood thinning medication or more than 81 mg of aspirin/day should discuss this with their doctor.
Patients would be best advised to refrain from simultaneously using non-steroidal anti-inflammatories, since it has been well demonstrated this class of drugs actually impairs the ability of our body to re-grow new cartilage.
Pentosan is available from our laboratory on prescription as a subcutaneous injection, sterile nebules or a more convenient nasal spray.
We recommend to use Pentosan in combination with Collagen capsules which increase its effectiveness.
Ghosh.P., “The pathophysiology of osteoarthritis and the rational for the use of Pentosan Polysulfonate for its treatment.” Seminars in Arthritis and Rheumatism 1999, 28(4): 211-267.