Catechol-O-Methyltransferase (COMT) The Catechol-O-Methyltransferase (COMT) system helps to break down certain neurotransmitters such as dopamine, norepinephrine and epinephrine and also catechol hormones such as estrogens. Some flavanoids are also metabolised by this enzyme such as Quercetin, Rutin, Luteolin, EGCG (green tea). COMT is an enzyme that transfers methyl groups and by transferring a methyl group … Continue reading Catechol-O-Methyltransferase (COMT)